I don't see it working if you have them marry young. Not only would none of the things you mention happened but LEX LUTHOR would never happen. Lois wouldn't never go after him the way she did in the Pilot episode. She would never date him. There would be no need for Clark to be jealous of him etc.
I agree that to do this you would have to pick a smaller change. Like Lois realizing she liked Clark say when they go to Smallville. That way she is already involved with Luthor. She has treated Clark badly, Cat has tried to put on the moves and can continue to do so, etc.
