Okay, I got it. It's from We Have a Lot to Talk About, and Bill Church Senior introduces his son to Mindy.
Church Senior: "Son, I know what you're thinking... the old man's gone soft from that heart attack, married his pretty nurse and now he's a few grapes shy of a bunch. But I'll tell you, I've never seen things clearer... or known with more absolute fervor my true destiny."
Church Junior: "I'm guessing I'll need a drink."
If anybody is interested in posting a quote, here's your chance. You've got 48 hours. *g*