I think I've always called adults, excluding teachers, by their first names. From my friends' grandmother (who went by Nan), from my dad's employees, to the older folk down the street I remember talking to a lot, it was usually by first name.

When dealing with my family, I've found myself dropping the aunt/uncle when dealing with my parents' siblings, but mostly in thought or conversation about them. And sometimes calling my mom by her first name, but that's usually only at the family reunion. If you say Mom, you'll have about 15 women look. But if you say Terri, you'll get the right person. At the family reunion is also when I drop my mom's siblings honorifics when talking to/about them, but there's 50+ people at those, of 4 different generations. It's easier.

"You need me. You wouldn't be much of a hero without a villain. And you do love being the hero, don't you. The cheering children, the swooning women, you love it so much, it's made you my most reliable accomplice." -- Lex Luthor to Superman, Question Authority, Justice League Unlimited