Lois was first referred to as Mad Dog Lane by Jimmy in Neverending Battle in S1:

CLARK: Jimmy?

JIMMY: Yo, C.K.

CLARK: Tell me something ... Is Lois always so aggressive going after stories?

JIMMY: Does the phrase 'Mad Dog Lane' sound about right?

CLARK: *Seriously*.

JIMMY: Seriously? Yeah. But I've never seen her *this* worked up. This Superman guy has really pushed her buttons.


Athos: If you'd told us what you were doing, we might have been able to plan this properly.
Aramis: Yes, sorry.
Athos: No, no, by all means, let's keep things suicidal.

The Musketeers