This is from "Pheromone, My Lovely."
Clark is talking about playing hooky from work. Lois mentions that she had fun in high school. She was a member of the chess club and math club. In the pose she's in in this picture, she is saying,
"What are you saying, Clark? That I'm not a fun person? That I don't know how to have fun?"
This happens just before they get sprayed by Miranda.