In the current comics continuity she married Pete Ross, one of Clark's friends from Smallville, but they eventually divorced. They had one son named Clark - presumably CK was the godfather. Pete is bringing him up while Lana pursues her career. Ross was a senator under President Luthor (the comics universe is VERY different from L&C in this respect) and learned Clark's identity from Luthor, although Luthor was subsequently memory-wiped so he forgot.
There have been numerous variations in the comics, films, etc, in different eras, of course.
I did think that in the Lana episode of L&C they mentioned that the L&C version was engaged to someone, but apparently not.
