Lois Lane has often been accused of being "blind". What if that became literal?
I challenge you to write a fic in which Lois physically cannot see. It could be permanent or temporary; she could be born blind, or lose her sight in the line of duty. Anything goes.
How would this affect her relationship with Clark/Superman? Would she figure out his secret quicker, or would she have more of an excuse for not putting the pieces together? What about her investigations? And perhaps most importantly: Would Clark be even
more annoyingly over-protective than usual?