My favorite TV show of all time is Babylon 5, where there is terrific chemistry between a lot of the characters.
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John and Delenn - the primary romantic couple

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Londo and G'Kar - ambassadors from two warring races - whose very adversarial relationship took a number of surprising twists and turns over the course of the series.

And a L&C link: Tracy Scoggins showed up on the 5th Season of the show as the space station commander, 4 years after leaving L&C...

But the best chemistry for me has been with Lois and Clark (not surprisingly), and with Lee and Amanda on Scarecrow and Mrs. King. It was a joy watching their relationship develop, just as with L&C.
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And another L&C link: Beverly Garland played Amanda's mother...


"Our thoughts form the universe. They always matter." - Babylon 5