Take Luthor for one - I don't know about other people, but he annoys me so much I was kinda hoping he'd go bug a different fandom. So it's okay to kill him. He did. It's called Mutant X. Tho, from what I hear, he's a good guy. 
"You need me. You wouldn't be much of a hero without a villain. And you do love being the hero, don't you. The cheering children, the swooning women, you love it so much, it's made you my most reliable accomplice." -- Lex Luthor to Superman, Question Authority, Justice League Unlimited
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