I could see a case where Sam starts keeping track of her changes and trying to use it to his advantage (coming up with advancements for humans based upon her abilities, but I suspect it would be mostly just a notebook documenting her abilities. He probably would bring in a few other experts on aliens but find himself mostly disgusted with their lack of understanding. Lois would probably rebel from all of that (at least for a while) leading to her travel around the world.

CLARK: No. I'm just worried I'm a jinx.
JONATHAN: A jinx?
CLARK: Yeah. Let's face it, ever since she's known me, Lois's been kidnapped, frozen, pushed off buildings, almost stabbed, poisoned, buried alive and who knows what else, and it's all because of me.
-"Contact" (You're not her jinx, you're her blessing.)