What if the therapist in Madam X was Harley Quinn, out to get Superman because her Puddin' wanted to expand operations into Metropolis, and it had nothing to do with Lex aside from the criminal power vacuum he left behind?

Would she still target Lois (to draw Superman out this time)?
Would she target Clark too, since he gets so many Superman exclusives?
Would she go off in a completely new direction, and if so how would our investigative duo get involved?
Would Batman get involved, or are his hands full with Gotham?
Would you create different blanks and fill them in differently?

Have fun!

I want this crossover so much!

Maybe you could have Batman be gone. Think of the "Birds of Prey" 2002 U.S. TV series. It only lasted one season, but the timelines add up perfectly for a tale in the early 1990s after Batman disappears and while Huntress is still a child.

One can use the Mia Sara version of Dr. Harleen Quinzel/Harley Quinn.

Plus the complete series, one season, is available on on CWSEED
Birds of Prey

What if Bruce Wayne wasn't Batman yet? Maybe Clark/Superman somehow inspires him to become a hero in his own right to stop the spread of corruption filtering into Gotham?

Bumping idea because this needs to be written.