I got to wondering: What would happen if Lois and/or Clark met up with an alternate-universe version of either themselves or their significant other...who was the reverse gender? Could Lois or Clark put up with Louis Lane or Claire Kent? The worlds want to know!

Clark would probably have no major problem, although I can see some embarrassment at certain topics.

Lois I expect would clash with most alts of herself. What gender they are might make it worse.

Well, if they are attracted to the other's soul more than their physical characteristics, I could see a lot of awkwardness.

Canon Clark: (to self) "Oh man, this is awkward. I'm completely attracted to Louis Lane! But he's a GUY!"