It's not the infidelity per se; it's the thought of Lois being unfaithful to Clark or vice versa.
As opposed to me, where is IS about the infidelity, regardless of whether it is Lois/Clark cheating
with the other or
on them.
It is one of the few things that will make me stop reading a story that I have been enjoying by an author I love. Not always; depends on exactly how it's handled.
And at least one story I read didn't
quite cross my "personal comfort line" until almost the very end of the story. So I finished it, but am now much more hesitant about their stories.