Ha! I was going to suggest the Lois/Jimmy pairing! What would suck worse for Clark...seeing his soul mate (assuming Lois was still his soul mate) with a villain like Lex or with his very best (guy) friend? With the former, Clark knows Lois is with a bad guy and can hope she'll come to her senses. With the latter, Clark knows she's with a good guy and will probably never leave him, thus shattering all hope she will one day be with him.
